Tablets and capsules of Sceletium are being used successfully by a number of psychiatrists, psychologists and doctors with excellent results for anxiety states and mild to moderate depression; and they can also be used by the lay public as supplements to elevate mood and for stress and tension.

In addition to Sceletium's common use for the stress and mental fatigue of modern industrial living, Sceletium has been used as a natural supplement in:

In addition to these better-known clinical uses, there is some preliminary evidence that Sceletium may be of value as a supplement in drug addiction rehabilitation and alcohol rehabiliation support, as part of a formal program. Research directions for the future include evaluation of potential in cognitive enhancement, and the management of Parkinsons Disease and Alzheimers Disease.

Sceletium elevates mood and decreases anxiety, stress and tension, and it has also been used as an appetite suppressant by shepherds walking long distances in arid areas. In intoxicating doses it can cause euphoria, initially with stimulation and later with sedation. Long-term use in the local context followed by abstinence has not been reported to result in a withdrawal state. The plant is not hallucinogenic, and no severe adverse effects have been documented.

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