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Sceletium tortuosum plant flowering

Contraindications of Sceletium

Although there have been no confirmed reports of drug interactions, because of the neuro-receptor activities of Sceletium tortuosum there are theoretical interactions with other psychiatric medications and cardiac drugs. People taking any psychiatric drug (including all anti-anxiety drugs, sedatives, hypnotics, antidepressants and anti-psychotics and so-called designer or recreational drugs) or any cardiac medications, are advised not to take Sceletium-containing products.

As with most supplements and modern drugs, safety in pregnancy has not been established.

The National Institute of Mental Health in the United States have found Mesembrine the principle alkaloid responsible for psychoactivity in Sceletium tortuosum to be a serotonin-uptake inhibitor, keeping more serotonin in circulation, like Prozac. Since Prozac/SSRI's are contraindicated with MAOI, this would also go for Mesembrine. Also the results of taking it on top of other SSRI's are unpredictable, and it is known that alcohol can also cause side effects combined with many SSRI's.

Also see Sceletium side-effects.


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Sceletium tortuosum
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